By Abrams K.
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Extra info for A Bayesian Approach to Weibull Survival Models - Application to a Cancer Clinical Trial
39 This topic returns me to my scientific origins studying mouse embryos in the Institute of Animal Genetics in Edinburgh, where Waddington reported the amazing story of the gene Aristopedia in Drosophila, which he had induced to grow legs in place of eyes. These unusual flies then bred true, showing he had uncovered a gene that had been silenced for millions of xxix years and how this could be an essential component of normal differentiation. He called it epigenesis, and we fear today that some aspects of IVF may lead to deleterious epigenetic changes in children such as Angelmann or Beckwith–Wiedemann syndrome.
Now it is unusual for laboratories to fabricate their own medium since individual production is prone to error. The introduction of soft catheters has also become extremely competitive, with many manufacturers vying for our programs’ business. The introduction of recombinant gonadotropins has led to much more uniform and stable formulations that yield more reproducible responses in patients. The use of drugs designed to treat type II diabetes (metformin, rosiglitazone) has begun as an adjunct to treatment of patients with polycystic ovaries.
Cole R, Edwards RG, Paul J. Cytodifferentiation and embryogenesis in cell colonies and tissue cultures derived from ova and blastocysts of the rabbit. Dev Biol 1966; 13: 385–407. 13. Edwards RG. Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes. Nature 1965; 208: 349–51. 14. Edwards RG. Maturation in vitro of human ovarian oocytes. Lancet 1965; 2: 926–9. 15. Edwards RG, Donahue R, Baramki T, Jones H Jr. Preliminary attempts to fertilize human oocytes matured in vivo.
A Bayesian Approach to Weibull Survival Models - Application to a Cancer Clinical Trial by Abrams K.